AMR Call Rules and Guidelines



Grand Challenges Africa (GC Africa) is a scheme of the Africa Academy of Sciences initiated to support innovations that address Africa’s health and developmental challenges. The scheme seeks to promote Africa-led scientific innovations to help countries better achieve the Sustainable Development Goals (SDGs) by awarding seed and full grants to the continent’s most impressive solutions.

AAS implements GC Africa in partnership with the New Partnership for Africa’s Development Agency (NEPAD) and the Bill & Melinda Gates Foundation. The call is a joint initiative of GC Africa partners including Grand Challenges South Africa. This call is focused on the SDG3 targets with the overall objective of focusing African scientists to work in local and global partnerships on the ambitious but achievable goals of accelerating knowledge generation, developing and deploying interventions and innovations that will improve awareness of antimicrobial resistance, strengthen knowledge through surveillance and research, reduce infection incidence, optimise the use of antimicrobial agents, and develop the economic case for sustainable investment as well as defining the role of ecosystems, particularly the evolution of a microbial system shared by humans, animals, and other biological organisms, which will be critical to tackle current and future AMR challenges.

Eligibility Criteria

The call is open to African innovators working in African based, domestic organizations, including non-profit organizations, international organizations, government agencies, research and academic institutions. Please note that this call is not open to- for- profit making organizations, but for South African applicants applying for funding through Grand Challenges South Africa, they may be included as sub-contractors if they provide a service or capability that is not available among the project partners but essential for project completion.

Funding levels

The request for proposals for designing New Approaches to Characterize the Global Burden of Antimicrobial Resistance will fund: seed grants at up to USD $100,000 for a period of 2 years and full grants at up to USD $250,000 for a period of 3 years.  We expect that projects funded at either level with promising results will have the opportunity to apply for additional funding to build on initial success.  How many seed grants and how many full grants will be funded depends on the response to the request for proposals.  In all cases, individual project budgets should be representative of the scope and magnitude of the proposed mandate and carefully designed to get the best possible value out of the award.

  • Seed grants (funded at up to $100,000 USD) do not require extensive preliminary data and are meant to provide an opportunity to test particularly bold ideas, including applying approaches from outside the field or that bridge fields.  New approaches could be piloted as additions to ongoing funded projects.  The application process entails submission of a two-page application succinctly describing the new approach and how it will be tested.
  • Full grants - Open to investigators based in South African Institutions only (funded at up to $250,000 USD) do require substantial preliminary data and are meant to provide an opportunity to refine and rigorously test approaches, including those that have previously shown promise in controlled or limited settings. 

Key features of the GC Africa initiative are:

  • A short application form to lower the burden of entry
  • Rapid turnaround time: We select projects within approximately five months of the proposal submission.
  • Blinded review process: Proposals are sent to reviewers without an applicant’s identifying/personal or organizational information, so proposals are evaluated based on the merit of the idea and not the applicants resume

Successful proposals will be evaluated based on the following criteria:

  • Scientific and technical excellence, including a clear and rigorous conceptual framework for research activities
  • Innovation, including creativity of the project’s approach and clear differentiation from existing approaches
  • Unique project resources, including investigator and organization capabilities and potential to enhance intra - African collaborations, mentorship and supervision in future.
  • Value in terms of appropriateness of the budget and timelines relative to project complexity, risk, and potential impact.
  • Potential to lead to prevention and treatment solutions with substantial impact.


Application Instructions


Key dates and deadlines

Key Dates Event
March 29, 2018 Application period opens
May 16, 2018 Application deadline
May 28-June 01, 2018 Triage
June 14-20, 2018 Independent Review
August 2018 Decision Committee meeting
August 2018 Selections completed, and notifications sent
September-October 2018 Grant-making and awards announcement

Application Format

Subject to the AAS Data Privacy and Protection Policy, GC Africa may share information you provide to us (either orally or in writing) with third parties, including external reviewers, key partners and co-funders.

GC Africa initiative publishes its calls and requests for proposals once a year.  An applicant may submit multiple ideas in partnership with collaborators, but an individual Principal Investigator may lead the submission of only one proposal. Click here to view the current detailed challenge description. You may change your topic and edit your proposal any time before the application deadline.

The review and evaluation of your application are not based on your past history or institutional capabilities. Do not include personal or Institutional information and do not refer to potential project partners by names or other identifying information in the section describing your project. Proposals that do not adhere to these restrictions will be removed from consideration.

Proposals for Round 2 funding must be submitted prior to the submission deadline of 16 May 2018 18:00 GMT.

During the application process you will be required to confirm that you have read and understood the AAS Data Privacy and Protection Policy and these Rules and Guidelines and acknowledge that any information that you provide to us (either orally or in writing) will be subject to and handled in accordance with such provisions. South African innovators have to familiarize themselves with the  SAMRC Terms and Conditions of funding.

Review Process

The review of proposals is a critical element of the GC Africa initiative - its goal is to filter and harness creative ideas. For each round, we advertise a set of challenges carefully defined to elicit innovative responses to critical barriers in global health and development.


The AAS has put in place policies and procedures intended to restrict public dissemination of application materials. These policies and procedures include confidentiality agreements which external reviewers sign and that require reviewers destroy or return to AAS all copies of information acquired or created during the course of performing a review.  In some instances, however, we are unable to put in place confidentiality agreements or to police the use of application materials.

The AAS Data Privacy and Protection Policy sets out what AAS will do with the information that it collects from you during the grant/award application process and throughout the life of the grant/award (including all information relating to the grant/award application and, as applicable, any subsequent grant/award made).

Information that you supply to the AAS, including in any application and progress or update report, may be used by the AAS to process applications and administer grants/awards, for the purposes of audit and evaluation and to monitor the fairness of and trends in application decisions. Your information may be disclosed for these purposes only to individuals and organisations connected with the AAS, including funding partners, external peer reviewers and external committee members.  Your information may also be shared with selected third parties for the purpose of independent audit, evaluation and assessment of activities funded by the grant/award and their outputs and outcomes. All personal data will be stored and used by or on behalf of the AAS in accordance with the AAS Data Privacy and Protection Policy.

The AAS may publish details of successful grants/awards and their outputs, including your name, employing organisation, project title, a summary of the grant/award and its value and, in the case of grants/awards funding research, scientific/academic abstracts and lay summaries of research (e.g. via the internet or via publicly accessible databases or other modes of publicity).

The AAS may amend this Statement from time to time.  Any material changes in how the AAS collects, uses or shares your personal data will be posted on the AAS website at:

Review of Proposals

Due to the large number of proposals anticipated, applicants with proposals that are not selected for review will receive a notification of decline without specific feedback. Nonetheless, applicants are encouraged to submit ideas in future rounds. We will update our FAQ based on common themes to provide guidance for future applications.

The review process for GC Africa Calls is executed in six steps:

  1. Triage: AAS will constitute a triage team from its in-house pool of program staff and invited external experts. The triage teams will code proposals based on pre-defined criteria designed by AAS to ensure quick distribution to reviewers as well as remove incomplete proposals or those that are not responsive to the topic or other grant conditions. Based on the volume of applications, we may not be able to give individual feedback, but we will endeavour to give collective feedback to applicants.
  2. Independent review of proposals: Responsive proposals will be sent to internal and external reviewers who will be given an opportunity to evaluate and identify strong proposals to reflect a merit-based process for subsequent consideration by the decision-making committee. Reviewers will be instructed to review for the responsiveness to the topic, the level of innovation of the approach presented, the quality of the execution plan and potential for building strong collaborations for GC Africa Calls. The aim is to have each application reviewed by at least 2 independent reviewers. To avoid bias and minimize conflicts of interest, proposals will be sent to reviewers without the applicants’ personal and organizational information.
  3. Review and portfolio selection: Once comments and feedback are received from the reviewers, GC Africa will compile and share the final portfolio with the decision-making committee.
  4. Decline emails: All applicants will be notified of the status of their application, regardless of outcome. All rejected proposals will receive an email declination.
  5. Funder due diligence, legal review and grant-making: AAS will initiate the process of required due diligence and legal review, as appropriate and before issuing grant award letters to winner, this due diligence review ensures that the investigator and institution have the basic capacity to receive the award (taking into consideration legal requirements to which the AAS is subject) and perform the work described. Investigators will be contacted as part of the due diligence review.

Management of Conflict of Interest

To identify and avert conflicts of interest among reviewers, reviewers will not be permitted to review proposals from organizations with which the reviewer has self-identified conflicts of interest in accordance with the AAS Conflict of Interest Policy.

Key Elements of GC Africa Agreements

  1. Seed grants have a term of 24 months beginning on the project start date and the amount awarded is up to USD $100,000. Full grants have a term of 36 months and the amount awarded is up to USD $250,000.
  2. Grant funds may not be used to reimburse expenses incurred prior to the project start date.
  3. The applicant must return a fully executed agreement to the GC Africa Team no later than the date and time indicated on the agreement to receive a GC Africa GC Africa Calls award.  Funds will be disbursed upon the GC Africa teams’ receipt of a fully executed agreement. 
  4. No awardee is permitted to make sub-grants, but all awardees will be permitted to contract for services, up to a maximum of $20,000 USD.  Please be aware that this limit applies to funds paid by an awardee to any other organization (or an individual employed at another organization) as a subcontractor, including payments to co-PIs working at another organization.
  5. All awardees are entitled to purchase equipment, provided that the cost of each item is less than $3,000 USD and the total allocation for purchase of equipment does not exceed $10,000.
  6. Project funds may be used to cover the full direct costs of the project. Please read the Guidelines on Indirect Costs or contact the GCA team for clarifications on allowable and non-allowable costs
  7. Project funds may not be used to enrol human subjects in any research project subject to Institution Review Board (IRB) or Independent Ethics Committee (IEC) approval until such approval has been obtained for each site. Please refer to our policy on Use of Humans in Research for guidance.
  8. Awardees must agree to conduct and manage the project and the products, services, processes, technologies, materials, software, data other innovations, and intellectual property resulting from the project (including modifications, improvements, and further developments to “Background Technology”) in a manner that ensures “Global Access” as defined in the AAS Open Access Policy.

GC Africa Calls Reporting

All GC Africa awardees must prepare and submit an Annual and Final Financial and Scientific Reports. Awardees must submit the report electronically by the date agreed on the agreement using templates provided, on the Ishango Grants Management System.  The report should be a cumulative, stand-alone document that describes the work performed with the project funds during the project term. The scientific section of the report must include any technical data gathered, models developed, and summary conclusions.  The financial spend section of the report should include an account of the manner in which you spent the project funds. Annual reports are due 12 months after activation of the grant; final reports are due 6 months after the end of the grant period.

Frequently Asked Questions

Answers to any application questions can be found on the Frequently Asked Questions under our website.


Please direct all questions about this initiative, selection criteria, or application instructions by e-mail to the following address: